Angelina Jolie and Brad Pitt have donated $1million to a hospital in Missouri, according to reports.

The couple's contribution was announced on Saturday by Pitt's brother, Doug, who has apparently backed the donation with other members of the actor's family.

The money will help set-up an endowment fund for children's cancer specialists, as well as going towards the building of a new paediatric unit, according to the Springfield News-Leader.

In return for the donation, St. John's Hospital is to rename its cancer treatment building the Jane Pitt Pediatric Cancer Center.

The reported donation is the latest charitable act from Jolie and Pitt, who have denied recent rumours that their romance is on the rocks.

Angelina Jolie and Brad Pitt