Ellen DeGeneres has clashed with Republican presidential hopeful John McCain on the subject of gay marriage.

The chat show host recently announced that she plans to wed partner Portia De Rossi now that the state Supreme Court has overturned California's gay marriage law.

And she felt compelled to address what she called “the elephant in the room” when McCain joined her on The Ellen DeGeneres Show yesterday.

"I just believe in the unique status of marriage between man and woman," replied McCain when asked for his thoughts on the issue.

"And I know that we have a respectful disagreement on that issue."

DeGeneres responded (to cheers from the audience), "It just feels like there is this old way of thinking that we are not all the same. We are all the same people, all of us. You're no different than I am. Our love is the same."

Watch it go down below...